2013-0609

Biospecimen Banking and Biomarker Validation for Lung Cancer Early Detection in Cohort Receiving Low Dose Helical Computed Tomography Screening

Multicenter Overall Study Chair:

Samir Hanash, MD, PhD

Study Biostatistician:

Ziding Feng, PhD

MD Anderson Study Chair:

Jeremy Erasmus, MD

Study Co-Chairs:

Myrna Godoy, MD, PhD

Samir Hanash, MD, PhD

Project Manager and Operations Director:

Bijun Yang, PhD

Collaborators:

Brett Carter, MD

Gregory Gladish, MD

Therese Bevers, MD

Stephen Swisher, MD

George Eapen, MD

Ignacio Wistuba, MD

Edwin Ostrin, MD, PhD

Lewis Foxhall, MD

Brian Reed, MD

Carmel Dyer, MD

Research Nurse:

Joanne Gigstad

Biospecimen processing and management:

Dilsher Dhillon

Nikul Patel

Laura Dundrea

Protocol administration and management:

Shunte Scott

Sujaya Rao

Outreach:

Anissa Lewis

Dana Lee

Database:

Robert Liu

Allen Chen

Jean Caputo

Multicenter Support:

Janelle Hibberts

Susie Bullock

Jan Yungclas

Legal:

Ray Rufer

M. S. Pepe, R. Etzioni, Z. Feng, J. D. Potter, M. L. Thompson, M. Thornquist, M. Winget, and Y. Yasui. Phases of biomarker development for early detection of cancer. Journal of the National Cancer Institute, 93(14):1054–1061, July 2001. PMID: 11459866.

M.S. Pepe, Z. Feng, H. Janes, P.M. Bossuyt, and J.D. Potter. Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: standards for study design. JNCI Journal of the National Cancer Institute, 100(20):1432, 2008. PMCID: PMC2567415.

M.S. Pepe, Z. Feng, G. Longton, and J. Koopmeiners. Conditional estimation of sensitivity and speci­ficity from a phase 2 biomarker study allowing early termination for futility. Statistics in Medicine, 28(5):762, 2009. PMCID: PMC2745932.

Y. Huang, M. Sullivan Pepe, and Z. Feng. Evaluating the predictiveness of a continuous marker. Bio­metrics, 63(4):1181–1188, 2007.

Y. Qu, B. Adam, M. Thornquist, J.D. Potter, M.L. Thompson, Y. Yasui, J. Davis, P.F. Schellhammer, . Cazares, M.A. Clements, et al. Data reduction using a discrete wavelet transform in discriminant analysis of very high dimensionality data. Biometrics, 59(1):143–151, 2003.

Y. Yasui, D. McLerran, B.L. Adam, M. Winget, M. Thornquist, and Z. Feng. An automated peak identifi­cation/calibration procedure for high-dimensional protein measures from mass spectrometers. Journal of Biomedicine and Biotechnology, 2003:242–248, 2003.

Yutaka Yasui, Margaret Pepe, Mary Lou Thompson, Bao-Ling Adam, Jr. Wright, George L., Yinsheng Qu, John D. Potter, Marcy Winget, Mark Thornquist, and Ziding Feng. A data-analytic strategy for protein biomarker discovery: profiling of high-dimensional proteomic data for cancer detection. Biostat, 4(3):449–463, 2003.

Y. Yasui, M. Pepe, L. Hsu, B.L. Adam, and Z. Feng. Partially supervised learning using an EM-boosting algorithm. Biometrics, 60(1):199–206, 2004.

T. Randolph, B. Mitchell, D. McLerran, P. Lampe, and Z. Feng. Quantifying peptide signal in maldi-tof mass spectrometry data. Molecular and Cellular Proteomics, 4:1990–1999, 2005. PMID: 16195224.

D.F. McLerran, Z. Feng, O.J. Semmes, L. Cazares, and T.W. Randolph. Signal detection in high-resolution mass spectrometry data. Journal of Proteome Research, 7:276–285, 2008. PMID:18173224 PMCID: N/A; precedes mandate.

 S.S. Li, J. Bigler, J.W. Lampe, J.D. Potter, and Z. Feng. FDR-controlling testing procedures and sample size determination for microarrays. Statistics in medicine, 24(15):2267, 2005.

 Y. Zheng, T. Cai, and Z. Feng. Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers. Biometrics, 62(1):279–287, 2006.

 D. McLerran, W.E. Grizzle, Z. Feng, W.L. Bigbee, L.L. Banez, L.H. Cazares, D.W. Chan, J. Diaz, E. Izbicka, J. Kagan, et al. Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: sources of sample bias. Clinical chemistry, 54(1):44, 2008. PMID: 17981926 PMCID: N/A; precedes mandate.

 J. Marrero, Z. Feng, Y. Wang, M. Nguyen, A. Befeler, L. Roberts, R. Reddy, D. Harnois, J. Llovet, D. Normolle, J. Dalhgren, D. Chia, A. Lok, P. Wagner, S. Srivastava, and M. Schwartz. Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma. Gastroenterology, 137:110–118, 2009. PMCID: 2704256.

 J. Qiu, G. Choi, L. Li, H. Wang, S. J. Pitteri, S. R. Pereira-Faca, A. L. Krasnoselsky, T. W. Randolph, G. S. Omenn, C. Edelstein, M. J. Barnett, M. D. Thornquist, G. E. Goodman, D. E. Brenner, Z. Feng, and S. M. Hanash. Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera. J. Clin. Oncol., 26:5060–5066, Nov 2008. PMCID: PMC2574910.

 Z. Jin, Y. Cheng, W. Gu, Y. Zheng, F. Sato, A. Olaru, B. Paun, J. Yang, T. Kan, T. Ito, J. Hamilton, F. Selaru, Y. Mori, R. Agarwal, S. David, J. Abraham, H. Wolfsen, N. Shaheen, K. Washington, J. Wang, M. Canto, Y. Wagner, P. Romero, Z. Wang, K. Feng, R. Sampliner, and S Meltzer. A multicenter, double-blinded prevalidation study of methylation biomarkers for progression prediction in barretts esophagus. Cancer Research, 69(10):4112–4115, 2009. PMCID: 2752375.

 John Wei, Ziding Feng, Alan Partin, Elissa Brown, Ian Thompson, Lori Sokoll, Daniel Chan, Yair Lotan, Adam Kibel, Erik Busby, Mohamed Bidair, Daniel W Lin, Samir S Taneja, Rosalia Viterbo, Aron Y. Joon, Jackie Dahlgren, Jacob Kagan, Sudhir Srivastava, and Martin Sanda. Can Urinary PCA3 Supplement PSA In The Early Detection Of Prostate Cancer? Journal of Clinical Oncology. In press.

 Sokoll LJ, Sanda MG, Feng Z, Kagan J, Mizrahi IA, Broyles DL, Partin AW, Srivastava S, Thompson IM, Wei JT, Zhang Z, Chan DW. A prospective, multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness. Cancer Epidemiol Biomarkers Prev 19(5):1193-200, 5/2010. PMCID: PMC2867076.

Collaborating Institutions/Principle Investigators

Bijun Yang, PhD

Director, Research Planning & Development

713-563-7147

Bijun.yang@mdanderson.org

If you are interested in participating in the lung cancer early detection screening program, please visit:

https://www.mdanderson.org/prevention-screening/get-screened/lung-cancer-screening.html